ProMer is a technology that involves the genetic fusion of two proteins via a proprietary linker
Our publications (*,**) have demonstrated that this approach is capable on significantly increasing the half-life of biologicals without affecting their activity. In addition to prolonging half-life, this patented technology can be exploited to produce protein homodimers and heterodimers (e.g. bispecific single chain antibodies, bispecific ligands, immunotoxins, fluorescent proteins, etc.).
Possible ProMer applications:
The ProMer structure and length can be further adjusted according to unique features and mode of action of particular proteins.
Manufacturing process is simple since there is no need of additional chemical modifications
Proteins constructed with ProMer technology can be effectively produced in bacteria, yeast and mammalian cells.
*Construction, Purification, and Characterization of a Homodimeric Granulocyte Colony-Stimulating Factor. Molecular Biotechnology, October 2017, Volume 59, Issue 9–10, pp 374–384
**Generation of dimeric single-chain antibodies neutralizing the cytolytic activity of vaginolysin. Electronic Journal of Biotechnology, Volume 28, July 2017, Pages 52-57