ProMer technology
ProMer is a technology that involves the genetic fusion of two proteins via a proprietary linker
Our publications (*,**) have demonstrated that this approach is capable on significantly increasing the half-life of biologicals without affecting their activity. In addition to prolonging half-life, this patented technology can be exploited to produce protein homodimers and heterodimers (e.g. bispecific single chain antibodies, bispecific ligands, immunotoxins, fluorescent proteins, etc.).
Possible ProMer applications:
The ProMer structure and length can be further adjusted according to unique features and mode of action of particular proteins.
ProMer advantages:
Manufacturing process is simple since there is no need of additional chemical modifications
Proteins constructed with ProMer technology can be effectively produced in bacteria, yeast and mammalian cells.
References:
*Construction, Purification, and Characterization of a Homodimeric Granulocyte Colony-Stimulating Factor. Molecular Biotechnology, October 2017, Volume 59, Issue 9–10, pp 374–384
**Generation of dimeric single-chain antibodies neutralizing the cytolytic activity of vaginolysin. Electronic Journal of Biotechnology, Volume 28, July 2017, Pages 52-57